Version 8.2.1 iTunes update is understood to kill the ability of the Palm Pre to sync claims an article over on theiphoneblog. iTunes 8.2.1 is a minor update released by Apple and is available as a pop up when you open iTunes or launch Apple Software Update.

iTunes 8.2.1 delivers several important bug fixes along with addressing the issue with verification of Apple devices.

So with the release of iTunes 8.2.1 it looks like any chance of Palm’s boasted Palm Pre sync with iTunes has come to an end, unless of course Palm fines a way around it.